putative response to marijuana
Design choices include patients who are the general population of patients with the disorder, or one of the following groups: nonresponders or incomplete responders to other therapies, patients selected in open-trial designs who responded to marijuana, and naive versus experienced marijuana smokers. One proposed strategy, selecting subsets responsive to marijuana in an open manner (i.e., “enrichment design”), assumes that there may be subpopulations that are difficult to recognize marijuana seeds, except on the basis of their prior putative response to marijuana. Once identified, such patients are randomly assigned to a study drug or control group and are evaluated in a prospective manner.